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. 2021 Aug 11;12:676527. doi: 10.3389/fneur.2021.676527

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Copyright © 2021 Sanz Diaz, de las Heras Flórez, Carretero Perez, Hernández Pérez and Martín García.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative high-resolution electrophoresis reflecting the difficulty on reporting OCB results in specific cases. (A–C) Easily identifiable bands in CSF not present in the serum sample. (D) Guillain–Barré syndrome with a K-Index of 39.98, one easy to distinguish and possibly a second OCB, making it difficult to report the OCB status. (E) MS with a K-Index of 39.29, faint bands on CSF impossible to confirm on serum due to strong background, reported negative OCB. (F) Recurrent left optic neuritis without MS, with K-FLC levels < 0.03 and two reported OCB. OCB, oligoclonal band; CSF, cerebrospinal fluid; K-Index, kappa index; MS, multiple sclerosis; K-FLC, kappa free light chain.