Figure 1.

Expression levels of SLC16 family in cancerous and adjacent normal tissues. (a)The box plot showed the fluctuation of SLC16 family expression in cancer: Overall, the expression of SLC16A1 was the highest, and the expression of SLC16A12 was the lowest. The SLC16 family expression has a low dispersion in the data set, which is of great research value. (b)The heat map of the expression of the SLC16 family in each cancer compared to normal tissue: red represents upregulated expression, blue represents downregulated expression, and the shade of the color represents the degree of difference. Acute Myeloid Leukemia(LAML), Adrenocortical carcinoma(ACC), Cholangio carcinoma(CHOL), Bladder Urothelial Carcinoma(BLCA), Breast invasive carcinoma(BRCA), Cervical squamous cell carcinoma and endocervical adenocarcinoma(CESC), Colon adenocarcinoma(COAD), Uterine Corpus Endometrial Carcinoma(UCEC), Esophageal carcinoma(ESCA), Glioblastoma multiforme(GBM), Head and Neck squamous cell carcinoma(HNSC), Kidney Chromophobe(KICH), Kidney renal clear cell carcinoma(KIRC), Kidney renal papillary cell carcinoma(KIRP), Lymphoid Neoplasm Diffuse Large B-cell Lymphoma(DLBC), Liver hepatocellular carcinoma(LIHC), Brain Lower Grade Glioma(LGG), Lung adenocarcinoma(LUAD), Lung squamous cell carcinoma(LUSC), Skin Cutaneous Melanoma(SKCM), Mesothelioma(MESO), Uveal Melanoma(UVM), Ovarian serous cystadenocarcinoma(OV), Pancreatic adenocarcinoma(PAAD), Pheochromocytoma and Paraganglioma(PCPG), Prostate adenocarcinoma(PAD), Rectum adenocarcinoma(READ), Sarcoma(SARC), Stomach adenocarcinoma(STAD), Testicular Germ Cell Tumors(TGCT), Thymoma(THYM), Thyroid carcinoma(THCA), Uterine Carcinosarcoma(USC). (c) Correlation plot based on Spearman Correlation test results to show the correlation of gene expression among the SLC16 family members across all 33 cancer types: Among them, SLC16A4 and SLC16A12 have the strongest correlation. The correlation value was 0.54