Table 1.
Non-coding RNAs and PDAC tumorigenesis
| PDAC promoting | Aliases for gene (genecards.org/) | Gene location (genenames.org/) | Increased expression promoting other cancers (malacards.org/) |
|---|---|---|---|
| MicroRNA | |||
| miR-21 | MicroRNA 21 | 17q23.1 | Multiple cancers |
| miR-155 | MicroRNA 155 | 21q21.3 | Multiple cancers |
| miR-221/222 | MicroRNA 221/222 | Xp11.3/ Xp11.3 | Multiple cancers |
| miR-196b | MicroRNA 196b | 7p15.2 | Multiple cancers |
| miR-10a | MicroRNA 10a | 17q21.32 | Multiple cancers |
| Circular RNA | |||
| ciRS-7 | CDR1 Antisense RNA | Xq27.1 | Bladder cancer |
| circ-LDLRAD3 | Low Density Lipoprotein Receptor Class A Domain Containing 3 | 11p13 | No data |
| RHOT1 | Ras Homolog Family Member T1 | 17q11.2 | No data |
| ZMYM2 | Zinc Finger MYM-Type Containing 2 | 13q12.11 | Lymphoma, leukemia, myelofibrosis |
| IARS | Isoleucine TRNA Ligase 1, Cytoplasmic | 9q22.31 | Breast ductal adenocarcinoma |
| PDE8A | Phosphodiesterase 8A | 15q25.3 | Melanoma |
| Long non-coding RNA | |||
| H19 | H19 Imprinted Maternally Expressed Transcript | 11p15.5 | Wilms tumor 2, embryonal carcinoma, choriocarcinoma |
| HOTAIR | HOX Transcript antisense RNA | 12q13.13 | Gastrointestinal cancers, triple negative breast cancer |
| HOTTIP | HOXA Transcript At The Distal Tip | 7p15.2 | Glioma, small cell lung cancer |
| MALAT1 | Metastasis Associated In Lung Adenocarcinoma Transcript 1 | 11q13.1 | Acute monocytic leukemia, ovarian endometrial cancer |
| PVT1 | Plasmacytoma Variant Translocation 1 | 8q24.21 | Plasmacytoma, Hodgkin lymphoma, B-cell lymphoma |
| PDAC inhibiting | Aliases for Gene(genecards.org) | Gene location (genenames.org/) | Decreased expression in tumorigenesis of other cancers (malacards.org/) |
| MicroRNA | |||
| miR-34a | MicroRNA 34a | 1p36.22 | Multiple cancers |
| miR-100 | MicroRNA 100 | 11q24.1 | Multiple cancers |
| miR-217 | MicroRNA 217 | 2p16.1 | Chronic lymphocytic leukemia, nasopharyngeal carcinoma |
| miR-143 | MicroRNA 143 | 5q32 | Multiple cancers, incl. PDAC |
| Long non-coding RNA | |||
| GAS5 | Growth Arrest Specific 5 | 1q25.1 | Multiple cancers |
| MEG3 | Maternally Expressed 3 | 14q32.2 | Multiple cancers |
| ENST00000480739 | ribosomal protein L13a pseudogene 23 | 12q13.3 | Osteosarcoma |