Table 1.

In vitro evaluation results for inhibition of growth of L. donovani promastigotes.

Compound	Acyl chain type	Characteristic structural features of acyl chain	% Inhibition at 50 µM concentrationa	% Inhibition at 25 µM concentrationa
1a	Palmitoyl	Saturated	108	107
1b	Palmitoleoyl	C16:1 cisΔ9	109	108
1c	Oleoyl	C18:1 cisΔ9	51	10
1d	Erucoyl	C22:1 cisΔ13	108	107
1e	Palmitoyl	Saturated	107	107
1f	Oleoyl	C18:1 cisΔ9	108	65
1g	Erucoyl	C22:1 cisΔ13	109	110
1h	Linoleoyl	C18:2 cisΔ9,12	0	−18
1i	α-Linolenoyl	C18:3 cisΔ9,12,15	1	−16
2a	Palmitoyl	Saturated	108	107
2b	Palmitoleoyl	C16:1 cisΔ9	98	27
2c	Oleoyl	C18:1 cisΔ9	107	−19
2d	Erucoyl	C22:1 cisΔ13	109	107
2e	Linoleoyl	C18:2 cisΔ9,12	101	34
2f	α-Linolenoyl	C18:3 cisΔ9,12,15	9	0
3a	Palmitoyl	Saturated	109	108
3b	Palmitoleoyl	C16:1 cisΔ9	90	67
3c	Oleoyl	C18:1 cisΔ9	106	106
3d	Erucoyl	C22:1 cisΔ13	104	107
3e	Linoleoyl	C18:2 cisΔ9,12	69	0
3f	α-Linolenoyl	C18:3 cisΔ9,12,15	1	−14
Miltefosine	–	–	100	100
Erufosine	–	–	108	106

^a % Inhibition of growth of L. donovani promastigotes after incubation with the specified concentration for 3 days relative to control.