Table 3.

In vitro antiproliferative activity of compounds 10a–10j against human cancer cells.

Compounds	R 3	IC50 (μM)a
		MGC-803	HCT-116	PC-3	MCF-7
10a	Phenyl	6.62 ± 0.82	16.7 ± 1.03	28.2 ± 2.12	>50
10b	4-F-phenyl	0.92 ± 1.07	3.84 ± 0.14	4.72 ± 1.02	5.46 ± 0.87
10c	4-Br-phenyl	0.82 ± 0.11	1.49 ± 0.22	1.81 ± 0.26	1.40 ± 0.25
10d	2-Cl-phenyl	>50	18.7 ± 1.27	>50	22.1 ± 0.31
10e	4-CH3-phenyl	1.00 ± 0.08	2.48 ± 0.12	4.01 ± 0.07	1.68 ± 0.12
10f	2,4,6-(CH3)3-phenyl	>50	>50	>50	>50
10g	4-C(CH3)3-phenyl	12.8 ± 1.38	22.4 ± 1.67	18.9 ± 1.57	28.1 ± 1.82
10h	3,4-(OCH3)2-phenyl	14.2 ± 1.03	22.9 ± 1.34	36.6 ± 0.34	18.5 ± 0.81
10i	2-thienyl	16.8 ± 1.42	20.4 ± 1.92	27.8 ± 2.02	30.2 ± 1.81
10j	2-pyridyl	14.7 ± 1.88	24.8 ± 2.13	28.2 ± 1.98	34.2 ± 1.83
5-Fu	–	6.82 ± 1.12	14.4 ± 1.73	17.1 ± 1.42	12.1 ± 1.28

^aIn vitro antiproliferative activity was assayed by exposure for 48 h.