Table 2. Multivariate analysis of factors predicting death at 6 weeks among patients with mucormycosis, India*.
Variables | Survivors, n = 177 | Non-survivors, n = 110 | Odds ratio (95% CI) | p value |
---|---|---|---|---|
Mean age, y (SD) |
52.6 (15.1) |
54.7 (14.0) |
1.02 (1.00–1.04) |
0.03
|
Underlying disease | ||||
None | 10 (5.6) | 9 (8.2) | Referent | Referent |
Isolated COVID-19 | 42 (23.7) | 19 (17.3) | 0.56 (0.17–1.83) | 0.34 |
Diabetes mellitus | 109 (61.6) | 71 (64.5) | 0.92 (0.32–2.64) | 0.88 |
Traumatic inoculation | 8 (4.5) | 4 (3.6) | 1.30 (0.25–6.80) | 0.76 |
Others | 5 (2.8) | 3 (2.7) | 1.20 (0.18–7.81) | 0.85 |
Renal transplantation | 1 (0.6) | 2 (1.8) | 6.87 (0.42–113.19) | 0.18 |
Hematological malignancy |
2 (1.1) |
2 (1.8) |
1.60 (0.14–18.72) |
0.71 |
Site of involvement | ||||
Rhino-orbital | 117 (66.1) | 50 (45.5) | Referent | Referent |
Rhino-orbito-cerebral | 39 (22) | 39 (35.5) | 2.39 (1.30–4.40) | 0.005 |
Pulmonary | 8 (4.5) | 14 (12.7) | 3.26 (1.05–10.11) | 0.04 |
Other† |
13 (7.3) |
7 (6.4) |
1.29 (0.43–3.86) |
0.64 |
Admission to the intensive care unit |
32 (18.1) |
35 (31.8) |
2.87 (1.43–5.75) |
0.003
|
Combined medical surgical therapy |
135 (76.3) |
69 (62.7) |
0.77 (0.41–1.45) |
0.41 |
Combination of antifungals | ||||
Single antifungal drug | 95 (53.7) | 88 (80) | Referent | Referent |
Concurrent | 9 (5.1) | 5 (4.5) | 0.37 (0.09–1.44) | 0.15 |
Sequential | 73 (41.2) | 17 (15.5) | 0.17 (0.87–0.35) | 0.0001 |
*Values are no. (%) except as indicated. Bold text indicates statistical significance. COVID-19, coronavirus disease. †Includes cutaneous, stomach, disseminated, or other.