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. 2021 Aug 25;7(35):eabi6326. doi: 10.1126/sciadv.abi6326

Fig. 5. Preventive antimetastatic effect of the nanovaccine iPSC@RBC-Mlipo.

Fig. 5

(A) Schematic illustration of setting a 4T1-luc pulmonary metastasis model after vaccinating different groups twice. (B) In vivo bioluminescence imaging of 4T1-luc lung metastasis in different groups. The fluorescent signal is expressed in the form of counts. (C) Mean fluorescence intensity of tumor in lungs. (D) Body weights and (E) survival curves in different groups (n ≥ 5). (F) Cytokines levels in serum after treatment with groups. (G) Dissected lungs in groups and images of H&E-stained lung slides after vaccinating different groups. Scale bars, 50 μm. All data were expressed as means ± SEM. Statistical significance was calculated by one-way ANOVA with Tukey’s post hoc test. *P < 0.05, **P < 0.01, and ***P < 0.005. IFN-γ, interferon-γ; TNF-α, tumor necrosis factor–α.