TABLE 1.

Functionalities of PGT121 glycovariants targeting HIV-1_JRCSF-infected primary CD4⁺ T cells^a

Parameter	Trastuzumab†	PGT121*	PGT121 LALA*	PGT121 G0F†	PGT121 G0†	PGT121 G2F†	PGT121 G2†
Antibody binding	0.05	1.00	1.06	1.10	1.20	1.10	1.12
FcγRIIIa binding	0.64	1.00	0.70	1.18	1.82	1.05	1.63
%ADCC	0.10	1.00	0.72	1.39	1.85	1.12	1.72

^aAb binding, FcγRIIIa binding, and ADCC were measured as described in Materials and Methods. Respective values obtained for each assay are normalized to the value obtained by PGT121. *, 293F-derived MAbs; †, plant-derived MAbs.