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Schematic overview of the working model of how ASFV E120R protein negatively regulates type I IFN production. ASFV E120R protein negatively regulates type I IFN production by interacting with IRF3 and impairing the interaction between TBK1 and IRF3 to block IRF3 phosphorylation. E120R protein may inhibit IFN-β production both in the virus particle and in the cytoplasm. ISRE, IFN-stimulated response element.
