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. Author manuscript; available in PMC: 2021 Aug 25.
Published in final edited form as: Clin Cancer Res. 2020 Feb 18;26(11):2673–2680. doi: 10.1158/1078-0432.CCR-19-2135

Figure 1: Summary of the HRD-related predictors in the whole genome datasets.

Figure 1:

A: HRD score: the sum of the three allele-specific CNV-derived genomic scars (HRD-LOH + LST + ntAI)

B: Fraction of larger than 9 bp deletions versus deletions/insertions ratio

C: Fraction of microhomology-mediated deletions with larger or equal to 10 bp in length versus deletions/insertions ratio

D: Fraction of at least 10 bp long deletions in the BRCA1/2 intact and deficient patients, the groups were compared with Mann-Whitney U-test, the p-values are represented on the plots.

E: HRDetect, the “+” signs if one allele is compromised, the “*” represent homozygous loss of BRCA1/2