FIG. 8.

Phylogenetic conservation of the −200 region of the Fli-1 gene shown by the alignment of 5′ sequences of the mouse (1), human (1), and Xenopus Fli-1 (30) genes. The region spanning bp −280 to −180 of mouse and human Fli-1 genes, corresponding to bp −210 to −110 bp of the Xenopus homologous gene, is shown. Conserved sequences are boxed. Consensus DNA binding sites for GATA, ETS, or IRF family transcription factors are indicated above sequences by horizontal arrows. The position of the major transcription initiation −204 site found in SFFV-transformed cells is shown by a vertical arrow. Oligonucleotides (probes) used in EMSA (see text) are shown below the sequences.