Table 1.

Output of linear mixed model on cortisol levels with fixed effects of factors treatment (placebo/metyrapone) and time (10 time points of the saliva samples/condition) and random effects of the factor subject

	Estimate	SE	tStat	p value	95% CI (lower, upper)
Intercept Placebo at 3:45 A.M. (baseline for PL)	0.071	0.067	1.067	0.287	–0.060, 0.202
Metyrapone at 3:45 A.M. (baseline for M)	–0.044	0.090	–0.504	0.614	–0.215, 0.127
Placebo at 6:45 A.M.	0.503	0.086	5.871	<0.001	0.335, 0.672
Placebo at 7:00 A.M.	0.667	0.084	7.950	<0.001	0.502, 0.832
Placebo at 7:15 A.M.	0.861	0.084	10.263	<0.001	0.696, 1.026
Placebo at 8:30 A.M.	0.698	0.084	8.219	<0.001	0.531, 0.865
Placebo at 8:45 A.M.	0.704	0.087	8.081	<0.001	0.533, 0.875
Placebo at 9:00 A.M.	0.630	0.085	7.432	<0.001	0.463, 0.770
Placebo at 9:15 A.M.	0.587	0.087	6.737	<0.001	0.416, 0.758
Placebo at 9:30 A.M.	0.563	0.086	6.555	<0.001	0.394, 0.732
Placebo at 9:45 A.M.	0.563	0.088	6.371	<0.001	0.389, 0.737
Metyrapone at 6:45 A.M.	–0.430	0.121	−3.547	<0.001	−0.669, –0.192
Metyrapone at 7:00 A.M.	–0.849	0.120	−7.083	<0.001	−1.081, –0.638
Metyrapone at 7:15 A.M.	−1.161	0.120	−9.679	<0.001	−1.370, –0.925
Metyrapone at 8:30 A.M.	−1.149	0.125	−9.227	<0.001	−1.393, –0.904
Metyrapone at 8:45 A.M.	−1.142	0.125	−9.161	<0.001	−1.387, –0.897
Metyrapone at 9:00 A.M.	−1.209	0.121	−10.028	<0.001	−1.447, –0.972
Metyrapone at 9:15 A.M.	−1.253	0.124	−10.128	<0.001	−1.496, −1.010
Metyrapone at 9:30 A.M.	−1.025	0.121	−8.449	<0.001	−1.264, –0.787
Metyrapone at 9:45 A.M.	–0.992	0.125	−6.827	<0.001	−1.237, –0.747

tStat: t statistic; CI: confidence interval.