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. 2021 Aug 26;23:108–118. doi: 10.1016/j.omtm.2021.08.005

Table 2.

Pathological changes in major tissues and organs of rhesus macaques immunized with the inactivated vaccine and adjuvant control after challenge with the live virus.

Tissues
Control
Vaccine

(n = 22)
Challenge on 7 days after booster
Challenge on 150 days after booster
200 EU (n = 4) 100 EU (n = 3) 20 EU (n = 3) 100 EU (n = 18)
Lung +
Trachea +
Pulmonary lymph nodes +
Tracheal lymph nodes +
Cervical lymph nodes +
Brain
Heart ±
Liver ±
Spleen ±
Intestinal

+ indicates that all experimental animals had pathological changes; – indicates that all experimental animals had no pathological changes; ± indicates that some experimental animals had pathological changes but some had no pathological changes.