Table 2.
Pathological changes in major tissues and organs of rhesus macaques immunized with the inactivated vaccine and adjuvant control after challenge with the live virus.
| Tissues |
Control |
Vaccine |
|||
|---|---|---|---|---|---|
| (n = 22) |
Challenge on 7 days after booster |
Challenge on 150 days after booster |
|||
| 200 EU (n = 4) | 100 EU (n = 3) | 20 EU (n = 3) | 100 EU (n = 18) | ||
| Lung | + | – | – | – | – |
| Trachea | + | – | – | – | – |
| Pulmonary lymph nodes | + | – | – | – | – |
| Tracheal lymph nodes | + | – | – | – | – |
| Cervical lymph nodes | + | – | – | – | – |
| Brain | – | – | – | – | – |
| Heart | ± | – | – | – | – |
| Liver | ± | – | – | – | – |
| Spleen | ± | – | – | – | – |
| Intestinal | – | – | – | – | – |
+ indicates that all experimental animals had pathological changes; – indicates that all experimental animals had no pathological changes; ± indicates that some experimental animals had pathological changes but some had no pathological changes.