Table 2.
Pathological changes in major tissues and organs of rhesus macaques immunized with the inactivated vaccine and adjuvant control after challenge with the live virus.
Tissues |
Control |
Vaccine |
|||
---|---|---|---|---|---|
(n = 22) |
Challenge on 7 days after booster |
Challenge on 150 days after booster |
|||
200 EU (n = 4) | 100 EU (n = 3) | 20 EU (n = 3) | 100 EU (n = 18) | ||
Lung | + | – | – | – | – |
Trachea | + | – | – | – | – |
Pulmonary lymph nodes | + | – | – | – | – |
Tracheal lymph nodes | + | – | – | – | – |
Cervical lymph nodes | + | – | – | – | – |
Brain | – | – | – | – | – |
Heart | ± | – | – | – | – |
Liver | ± | – | – | – | – |
Spleen | ± | – | – | – | – |
Intestinal | – | – | – | – | – |
+ indicates that all experimental animals had pathological changes; – indicates that all experimental animals had no pathological changes; ± indicates that some experimental animals had pathological changes but some had no pathological changes.