Table 1.

Summary of the 3 patients demographics, time between COVID infection and onset of symptoms, clinical presentation, laboratory results before and after COVID infection, and thyroid imaging.

	Patient 1	Patient 2	Patient 3
Age	38 years old	33 years old	41 years old
Gender	Female	Female	Female
Clinical features	Anterior neck discomfort, thyroid enlargement, fatigue, dry skin, hair loss, depression	Palpitations, shortness of breath, fatigue	Persistent palpitations, insomnia
Time between COVID-19 infection and onset of symptoms	6 weeks	7 weeks	6 weeks
TSH before COVID	3.10 mIU/(0.34–5.6) 10 months before COVID	0.83 mIU/L (0.4–4.5) 6 months before COVID	NA
TSH after COVID	136 mIU/L (0.34–5.6)	<0.01 mIU/L (0.4–4.5)	0.01 mIU/L (0.4–4.5)
fT4 before COVID	1.13 ng/dL (0.93–1.7)	NA	NA
fT4 after COVID	0.2 ng/dL (0.93–1.7)	2.1 ng/dl (0.8–1.8)	1.9 ng/dL (0.8–1.8)
Thyroglobulin	NA	8.8 ng/ml (2.8–40.9)	2.4 ng/mL (2.8–40.9)
Thyroglobulin Antibodies (TGAb)	>1000 IU/ml (normal less than or equal to 1)	14 IU/mL (normal less than or equal to 1)	3 IU/mL (normal less than or equal to 1)
Thyroid Peroxidase Antibodies (TPO)	>900 IU/mL (normal less than 9)	NA	69 IU/mL (normal less than 9)
Thyrotropin Receptor Antibody (TRAb)	NA	<1 IU/L (normal less than or equal to 2)	1 IU/L (normal less than or equal to 2)
Thyroid Stimulating Immunoglobulin (TSI)	NA	309 (normal less than 140%)	89% (normal less than 140%)
Thyroid Ultrasound	Thyromegaly with a heterogenous and hypoechoic sonographic appearance	Mild thyromegaly with heterogeneous and diffusely hypervascular sonographic appearance	NA
Thyroid Uptake Scan	NA	47.1% (normal between 8 and 35)	0.09% (normal between 8 and 35)
Fine Needle Aspiration	Small number of follicular cells with mixed inflammatory cells, including groups of histiocytes with epithelioid morphology suggestive of granulomatous inflammation, without clear lymphocytic infiltration	NA	NA