Figure 5.

Differential expression of selected nuclear encoded mitochondrial transcripts further differentiates neuronal subpopulations. A–C, t-SNE cell atlases built with the subunits of the mitochondrial ribosome (A), the SLC25A family of transporters (B), and the electron transport chain Complex I (C). t-SNE cell atlases were overlaid with heat maps of the expression levels of selected subunits of protein complexes or transporters. B₁, Transporters diffusely expressed across brain regions or showing specific patterns of expression. B₂, Transporters Slc25a22, Slc25a37, and Slc25a42 preferentially expressed in glutamatergic cells (see Fig. 3A). B₃, SLC25A transporters annotated in the SFARI database associated with autism spectrum disorder (SLC25A12, SLC25A27, and SLC25A39) or whose expression is altered in postmortem autism brain samples (SLC25A12, SLC25A14, and SLC25A27).