Figure 7.

Silencing SOCS3 enhanced leptin-induced JAK2-STAT3-CD14/TLR4 activation in chondrocytes. The protein expressions of JAK2-STAT3 signaling, SOCS3, CD14, TLR4, and MMP-13 were measured by western blot analysis (a, d). The bar graph summarized data of blots for JAK2-STAT3 signaling (b, c), CD14 (e), TLR4 (f), MMP-13 (g), and SOCS3 (h). Data were presented as mean ± SD, n = 3. Independent sample t-test and one-way ANOVA were used to conduct statistical significance. Significant expression differences are shown as ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.