FIG. 8.

Ser¹³³-CREB phosphorylation by glutamate is inhibited by KN62 treatment. (A) Glutamate-induced Ser¹³³-CREB phosphorylation in the presence or absence of KN62 was analyzed by Western blotting from the same striatal extracts as used in the experiment in Fig. 7. (B) Densitometric measurements were performed in three independent experiments (representing nine striatal slices) in the presence or absence of KN62. Statistical analysis: *, P < 0.05 (unpaired Student’s t test) when comparing glutamate alone with control chambers.