Fig. 1.

Flow diagram of patients. ER, endoscopic resection; APC, argon plasma coagulation; CT, chemotherapy; RT, radiotherapy; BSC, best supportive care. Primary site means the lesion treated with the first tPDT. * Fifty-one patients treated with the first tPDT involved two patients who had been treated with porfimer sodium photodynamic therapy. **One patient was treated two times with planned tPDT owing to five lesions. *** Four patients were treated with chemotherapy/chemoradiotherapy for lymph node metastasis. Two patients were treated with radiotherapy for brain metastasis. One patient was treated with chemotherapy for intramural metastasis. Three patients were treated with chemotherapy for other cancers. ****One patient who had a residual lesion after the first tPDT was treated with APC followed by repeated tPDT. ***** One patient, who achieved L-CR after the first tPDT, had intramural metastasis, and was then treated with chemotherapy followed by repeated tPDT