Table 3.

Adverse events related to repeated tPDT

Local adverse events (25 sessions)	CTCAE_v5.0 grade				Total (%)	Rate of grade 3–4 (%)
	1	2	3	4
Esophageal hemorrhage	0	0	0	0	0	0
Esophageal stenosis	2 (8.0%)	3 (12.0%)	1 (4.0%)	0	6 (24.0%)	1 (4.0%)
Esophageal perforation	0	0	1 (4.0%)	0	1 (4.0%)	1 (4.0%)

Systemic adverse events (23 sessions)	CTCAE_v5.0 grade				Total (%)	Rate of grade 3–4 (%)
	1	2	3	4
Esophageal pain	10 (43.5%)	0	0	0	10 (43.5%)	0
Nausea	9 (39.1%)	0	0	0	9 (39.1%)	0
Fever	5 (21.7%)	0	0	0	5 (21.7%)	0
Skin photosensitivity	0	0	0	0	0	0
AST increased	3 (13.0%)	0	0	0	3 (13.0%)	0
ALT increased	1 (4.3%)	0	0	0	1 (4.3%)	0
Blood bilirubin increased	0	0	0	0	0	0