Table 3.
Number of women with incident fractures and number of fractures stratified by frailty status at (A) age 75 and (B) age 80
| No. of women with at least one fracturea | No. of fracturesb | Incidence rate ratio | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Nonfrail | Frail | Nonfrail | Frail | |||||||
| (A) Frailty status at age 75 | n = 799 | n = 245 | p value | |||||||
| Fractures in the 5 years between 75 and 80 | No. | (%) | No. | (%) | No. | (fractures/1000 person-years)c | No. | (fractures/1000 person-years)c | IRRd | |
| Any | 153 | (19.1) | 61 | (24.9) | 0.051 | 213 | (55.5) | 85 | (78.1) | 1.41 (1.08–1.82) |
| Major osteoporotic | 122 | (15.3) | 49 | (20.0) | 0.080 | 163 | (42.5) | 67 | (61.6) | 1.45 (1.07–1.99) |
| Hip | 30 | (3.8) | 18 | (7.3) | 0.019 | 31 | (8.1) | 19 | (17.5) | 2.16 (1.15–3.95) |
| Vertebral | 42 | (5.3) | 23 | (9.4) | 0.019 | 65 | (16.9) | 33 | (30.3) | 1.79 (1.14–2.76) |
| Frailty index (mean, SD) | 0.14 | (0.05) | 0.36 | (0.10) | ||||||
| (B) Frailty status at age 80 | n = 434 | n = 281 | ||||||||
| Fractures in the 5 years between 80 and 85 | No. | (%) | No. | (%) | No. | (fractures/1000 person-years) | No. | (fractures/1000 person-years) | IRR | |
| Any | 92 | (21.2) | 85 | (30.2) | 0.006 | 143 | (68.7) | 132 | (103.9) | 1.51(1.18–1.93) |
| Major osteoporotic | 81 | (18.7) | 76 | (27.0) | 0.008 | 121 | (58.2) | 110 | (86.6) | 1.46 (1.12–1.91) |
| Hip | 32 | (7.4) | 30 | (10.7) | 0.125 | 36 | (17.3) | 33 | (26.0) | 1.50 (0.91–2.48) |
| Vertebral | 29 | (6.7) | 36 | (12.8) | 0.005 | 38 | (18.3) | 53 | (41.7) | 2.28 (1.48–3.56) |
| Frailty index (mean, SD) | 0.16 | (0.05) | 0.36 | (0.09) | ||||||
aFirst fracture used as endpoint. A woman could be included in multiple categories if fractures at different sites were sustained during the follow-up
bMultiple fractures in the same woman are included in the count
cIncidence rate (IR)
dIncidence rate ratio, reference category nonfrail