Fig. 5.

In vivo effect of NOS inhibition on myocardial oxygen balance at rest and during exercise in Normal and DM + HFD + CKD swine. Normal swine showed increased oxygen extraction (MEO₂. a), lower coronary venous oxygen saturation (cv SaO₂, b) and coronary venous partial oxygen pressure (cv pO₂, c), while DM + HFD + CKD swine showed no change in oxygen extraction (d), coronary venous oxygen saturation (e) or coronary venous partial oxygen pressure (cv pO₂, f) following the inhibition of NO synthase with N_ω-Nitro-L-arginine (NLA) during exercise. Values are mean ± SEM. DM + HFD + CKD: n = 6, Normal: n = 7. *P < 0.05 versus corresponding Control by two-way ANCOVA for repeated measures