Figure 5.
Effect of acidic pH on all variants expressed in Xenopus oocytes
Normalized currents measured for WT and all four variants at pH 5.3 and pH 6.3, leak-subtracted as described in Subjects and methods. For variants p.Thr570Ile and p.Ile607Thr, values are significantly different from those of WT at all voltages (p < 10−5, Student’s t test). For variants p.Ala413Val and p.Val772Ala, values are not significantly different from WT (p > 0.05, Student’s t test). Same data as (A) shown at higher magnification in (B). All error bars indicate SEM.