Figure 2.
Associations of systemic FH, FHR-1, FHR-2, FHR-3, FHR-4A, and FHR-5 with AMD variants at the CFH locus
The variants depicted are the lead variants identified in the International AMD Genomics Consortium AMD GWAS at the extended CFH locus in chromosome 1.15 Variants in blue are protective for advanced AMD and variants in red are risk-conferring in the primary analysis. The number refers to the signal identification order. If a p value is lower than 0.05, it is represented with one star (∗), if it is lower than 0.01, with two (∗∗), and if it is lower than 0.001, with three stars (∗∗∗). A dash (-) indicates a non-significant p value. The rare variant rs121913059 (1.3) was not present in our cohort, and the variant rs14855336 (1.4) was present in only one individual. Therefore, no analyses were performed for these two variants (gray).
NS = non-significant; NA = not applicable (variant not analyzed)