Table 2.

AMD haplotypes at the extended CFH locus are strongly associated with FHR protein concentrations: FHR1-2, FHR2-2, FHR-3, FHR-4A, and FHR-5

			FHR1-2				FHR2-2				FHR-3				FHR-4A				FHR-5
Ha	Overall haplotype frequency	OR association with AMDb	B	SE.	p value	pFDR	B	SE.	p value	pFDR	B	SE.	p value	pFDR	B	SE	p value	pFDR	B	SE	P value	pFDR
H1	0.375	Reference	Reference				Reference				Reference				Reference				Reference
H2	0.162	0.36	−0.626	0.084	7.48 × 10−13	4.49 × 10−12	−0.920	0.093	<0.001	<0.001	−0.019	0.073	0.793	0.865	−1.012	0.089	<0.001	<0.001	−0.363	0.100	3.10 × 10−4	0.001
H3	0.148	0.30	−1.013	0.092	<0.001	<0.001	−0.047	0.112	0.676	0.811	−0.740	0.078	<0.001	<0.001	−0.140	0.096	0.146	0.263	0.143	0.108	0.187	0.299
H4	0.141	0.68	−0.125	0.087	0.153	0.269	−0.310	0.097	0.002	0.006	0.993	0.075	<0.001	<0.001	−0.533	0.093	1.83 × 10−8	1.01 × 10−7	−0.356	0.104	0.001	0.003
H5	0.059	0.59	−0.519	0.123	2.95 × 10−5	1.18 × 10−4	−0.482	0.138	0.001	0.003	0.367	0.108	0.001	0.003	0.227	0.130	0.082	0.174	−0.369	0.145	0.012	0.035
H6	0.045	1.39	−0.254	0.139	0.069	0.151	−0.358	0.155	0.022	0.057	−0.132	0.120	0.274	0.395	0.206	0.149	0.168	0.281	−0.106	0.167	0.524	0.650
H7	0.019	0.44	−1.628	0.304	1.46 × 10−7	7.01 × 10−7	−0.069	0.308	0.823	0.884	−0.907	0.182	9.44 × 10−7	4.25 × 10−6	−0.394	0.232	0.090	0.182	0.339	0.261	0.194	0.304
H8	0.010	not associated	0.164	0.275	0.550	0.671	−0.008	0.378	0.983	0.997	0.775	0.292	0.008	0.024	−0.537	0.340	0.114	0.216	−0.006	0.387	0.987	0.997
H9	0.025	1.54	0.134	0.176	0.447	0.585	−0.023	0.196	0.909	0.949	−0.043	0.151	0.776	0.860	−0.164	0.188	0.383	0.530	0.029	0.210	0.891	0.943

See legend for Table 1.