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. 2021 Jul 13;108(8):1385–1400. doi: 10.1016/j.ajhg.2021.05.015

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Circulating concentrations of FHL-1 and FHR-1 to FHR-5 are elevated in AMD-affected individuals

Boxplots of FH (A), FHL-1 (B), and FHR-1 to FHR-5 (C–G) protein concentrations measured in plasma samples of 352 individuals with advanced AMD and 252 phenotyped control individuals from the Cambridge AMD study.²⁶^,²⁷ Protein concentrations are expressed as nM. Individuals with AMD show statistically significant elevated concentrations of FHL-1 and FHR-1 through FHR-5 in comparison to controls, whereas no significant difference between individuals with AMD and controls was observed for FH concentrations. Unadjusted p values were obtained from Wald tests via linear-regression models and are presented together with p values adjusted for sex, age, and the first two genetic principal components (as estimated within the IAMDGC study²). (H) Pairwise Pearson’s correlation coefficients (r) between the seven protein concentrations for the 252 control samples. Some modest correlation is observed between FH and FHR-5, FHL-1 and FHR-3, FHR-1 and FHR-3, and FHR-2 and FHR-5.