Figure 3.
GWASs of circulating concentrations of FHR-1 through FHR-5 reveal a strong genome-wide-significant signal spanning the CFH locus
Regional plots show the genome-wide-significant (p < 5 × 10−8) association signals from the GWASs of FHR-1 through FHR-5 concentrations (A–E) at the CFH locus on chromosomal region 1q31.3. (F) The equivalent CFH region for the GWAS of FHL-1 concentrations (no genome-wide-significant association regions were observed). The most associated variant is denoted by a purple diamond and is labeled by its rs number. The other surrounding variants are shown by circles colored to reflect the extent of linkage disequilibrium with the most associated variant (on the basis of the European [EUR] population genotype data originated from the 1000 Genomes Project, November 2014). A diagram of the genes within the relevant regions is depicted below each plot. Physical positions are based on NCBI RefSeq hg19 human genome reference assembly.