Figure 4.
Established AMD-risk variants at the CFH locus are associated with circulating FHR-1, FHR-2, FHR-3, and FHR-4 concentrations in control individuals
Boxplots of FHR concentrations by variant genotype for those CFH variants that were established as conferring AMD risk in the IAMDGC study2 and that showed genome-wide-significant (p < 5 × 10−8) associations in 252 controls from the Cambridge AMD study26,27 cohort (Table 3). p values and beta values from Wald tests using linear-regression models adjusted for sex, age, and the first two genetic principal components (as estimated within the IAMDGC study) are indicated in the note at the bottom of each plot.