TABLE 7.

Distribution of the allele carrying the two polymorphisms observed in XP4BE cells in the coding region of the gene for the catalytic subunit of pol δ

Geno-typea	XP variant skin fibro-blasts	Tumor-derived cell line(s)	Normal cells
+/−	XP4BE	2 osteosarcomas	4 foreskin-derived fibroblast lines
	XP1KA	3 neurofibrosarcomas	Lymphoblastoid immortal line
	XP3RO
−/−	HFXP	Adenocarcinoma (HeLa)
+/+	XP115LO	6 neurofibrosarcomas	16 foreskin-derived fibroblast lines
	XP5KA	4 fibrosarcomas	3 skin biopsy fibroblast cell lines
	XP6KA	2 adenocarcinomas	Lymphoblastoid immortal line
	XP7TAC	Nephroblastoma, Wilms’ tumor

^a+/+, two wild-type alleles; +/−, one allele with G · C→A · T transitions at positions 375 and 409; −/−, polymorphisms on both alleles. Homozygosity cannot be distinguished from hemizygosity.