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. 2021 Aug 21;16:5675–5692. doi: 10.2147/IJN.S318363

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© 2021 Liu et al.

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R-M@CS-PAA NPs-treated DCs enhanced the cytotoxicity of OT-I CD8⁺ T cells to B16F10-OVA cells. (A) BMDCs were co-cultured with B16F10-OVA cells for 48 h, and the percentage of OVA⁺ BMDCs was detected by FCM. (B-F) In the presence of different NPs, BMDCs, OT-I CD8⁺ T cells, and B16F10-OVA cells were co-cultured for 48 h. The ratio of IFN-γ⁺ (B), TNF-α⁺ (C), granzyme B⁺ (D), and perforin⁺ (E) OT-I CD8⁺ T cells, and the proliferation of B16F10-OVA cells (F) were examined by FCM. (G) The expression of IL-12p70, TNF-α, IFN-β, and IFN-γ in the serum of mice treated with different NPs was detected by ELISA assay. *p < 0.05, **p < 0.01.