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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2021 May 16;69:193–201. doi: 10.1016/j.conb.2021.04.003

FIGURE 2:

FIGURE 2:

Examples of key CRISPR effectors useful for probing schizophrenia-relevant mechanisms in hiPSC-derived neural cultures: the initial CRISPR/Cas9 targeted DNA cleavage system, CRISPRa, CRISPRi, CRISPR DNA editing systems, CRISPR DNA methylation and CRISPR histone modification. VPR = VP64-p65-Rta; KRAB = Krüppel associated box; CDA = cytidine deaminase; ADA = adenosine deaminase; TET = ten-eleven translocation methylcytosine dioxygenase; DNMT3A = DNA methyltransferase 3A; HMT = histone methyltransferase; HDM = histone demethylase; HAT = histone acetyltransferase; HDAC = histone deacetylase; HUbq = histone ubiquitinase. Info from refs46–49,64.