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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2021 May 3;69:170–177. doi: 10.1016/j.conb.2021.03.015

Figure 2. Modes of astrocyte-neuron contact-contact mediated interactions.

Figure 2.

(Left) Astrocytes mature morphologically concurrently with synapse development. Cooperation between developing astrocytes and neurites are critical in stabilizing trans-synaptic connections, resulting in a functional tripartite synapse. (Right) On the other hand, astrocyte-neuron contacts may act as a negative regulator of astrocyte overgrowth that would otherwise encroach into the forming synapse and prevent synaptogenesis.