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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2021 Apr 30;69:139–148. doi: 10.1016/j.conb.2021.03.011

Figure 1. Regulation of autophagy in the developing axon.

Figure 1

Schematic showing positive (upper) and negative (lower) regulators of axonal autophagy. Diagram integrates findings from a range of different model systems. Recently identified players include (1) Positive regulators AP-4E (adaptor protein complex component), Alfy/WDFY3 (WD40 repeat and FYVE domain protein), and PLEKHG5 (Rab GEF). (2) Negative regulators RPM-1 (E3 ubiquitin ligase that degrades UNC-51/ULK autophagy initiating kinase) and Chondroitin Sulfate (CS)/PTPRs/cortactin pathway. mTOR inhibition of autophagy is noted with a question mark because its role in regulating autophagy in the nervous system generally and axon development remains disputed.