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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2021 Apr 30;69:139–148. doi: 10.1016/j.conb.2021.03.011

Figure 2. Regulation of autophagy during presynaptic development.

Figure 2

Schematic showing how different molecular players regulate autophagy during presynaptic development. Shown are integrated findings from different model systems and cultured neurons. Positive regulators are the Kif1A kinesin that affects Atg9 presynaptic delivery and PLEKHG5, which is a GEF for Rab26. Negative regulators of presynaptic autophagy include the active zone scaffold Bassoon and the RPM-1 ubiquitin ligase. Also noted is the inhibitory role autophagy plays in regulating levels of BRP and active zone development.