TABLE 1.

Proteomics analysis of 8‐week‐old P497S UBQLN2 mice and age‐matched controls (WT356 UBQLN2 and Non‐Tg animals) comparing the log₂ ratios of P497S/WT356, P497/Non‐Tg, and WT356/Non‐Tg animals in the lumbar SC and hippocampus

Protein Id	Gene symbol	Description	log2 Hippo (P497S/WT356)	p value	log2 Hippo (P497S/Non‐Tg)	p value	log2 Hippo (WT356/Non‐Tg)	p value	log2 Lumbar SC (P497S/WT356)	p value	log2 Lumbar SC (P497S/Non‐Tg)	p value	log2 Lumbar SC (Non‐Tg/WT356)	p value	log2 ratio
sp|Q9CY58|	Serbp1	PAIRB_MOUSE Plasminogen activator inhibitor 1 RNA‐bp	−0.066	0.176	−0.064	0.558	0.002	0.986	−0.117	0.330	0.0446745	0.4184232	−0.083	0.244
sp|P07758|	Serpina1a*	A1AT1_MOUSE Alpha‐1‐antitrypsin 1‐1	1.347	0.191	1.035	0.243	−0.312	0.640	0.416	0.252	0.0801778	0.1739446	−0.036	0.366
sp|P22599|	Serpina1b	A1AT2_MOUSE Alpha‐1‐antitrypsin 1‐2	1.408	0.165	1.113	0.214	−0.295	0.591	0.425	0.197	0.2422415	0.2390785	−0.110	0.270
sp|Q00897|	Serpina1d	A1AT4_MOUSE Alpha‐1‐antitrypsin 1‐4							0.560	0.048	0.4144827	0.0665841	0.089	0.614
sp|Q00898|	Serpina1e	A1AT5_MOUSE Alpha‐1‐antitrypsin 1‐5	1.486	0.190	0.796	0.322	−0.690	0.386	0.652	0.313	0.1900601	0.5501875	−0.235	0.589
sp|P07759|	Serpina3k	SPA3K_MOUSE Serine protease inhibitor A3K	1.388	0.211	1.146	0.257	−0.242	0.621	0.397	0.298	0.1034186	0.5541651	−0.059	0.747
tr|G3X8T9|	Serpina3n	G3X8T9_MOUSE Serine (Or cys) peptidase inhibitor, 3N	0.662	0.233	0.754	0.195	0.092	0.473	0.352	0.124	0.318729	0.353001	−0.098	0.826
sp|Q9D154|	Serpinb1a*	ILEUA_MOUSE Leukocyte elastase inhibitor A	0.570	0.169	0.761	0.096	0.191	0.332	0.044	0.524	0.182243792	0.729305304	−0.192	0.700
sp|Q8VHP7|	Serpinb1b	ILEUB_MOUSE Leukocyte elastase inhibitor B	1.254	0.241	1.270	0.237	0.016	0.832	−0.008	0.905	0.3379195	0.3289914	−0.059	0.887
sp|Q60854|	Serpinb6	SPB6_MOUSE Serpin B6	0.085	0.483	0.039	0.731	−0.046	0.182	0.116	0.099	0.0639798	0.7973305	−0.588	0.395
tr|O08804|	Serpinb6b	O08804_MOUSE NK13	0.096	0.563	0.043	0.808	−0.053	0.598	0.162	0.249	−0.1165423	0.0305189	−0.081	0.194	−1.000
sp|O08800|	Serpinb8	SPB8_MOUSE Serpin B8	−0.204	0.307	−0.411	0.103	−0.206	0.406							−0.750
tr|O08797|	Serpinb9	O08797_MOUSE Protein Serpinb9	0.204	0.335	0.038	0.831	−0.166	0.057	0.128	0.075	−0.0034693	0.9759878	−0.036	0.812	−0.500
sp|P32261|	Serpinc1*	ANT3_MOUSE Antithrombin‐III	1.055	0.424	1.274	0.367	0.220	0.486	0.374	0.279	0.0343605	0.5043039	0.042	0.422	−0.250
sp|Q07235|	Serpine2	GDN_MOUSE Glia‐derived nexin	0.155	0.192	0.000	0.999	−0.155	0.047	−0.035	0.464	−0.0394735	0.8658744	−0.068	0.808	0.000
sp|P97298|	Serpinf1	PEDF_MOUSE Pigment epithelium‐derived factor	0.208	0.073	0.025	0.823	−0.183	0.203	0.029	0.919	−0.0073329	0.9361391	−0.012	0.755	0.250
sp|P97290|	Serping1	IC1_MOUSE Plasma protease C1 inhibitor							0.325	0.125	0.667654	0.0549768	0.108	0.704	0.500
sp|P19324|	Serpinh1	SERPH_MOUSE Serpin H1	0.187	0.612	0.035	0.921	−0.151	0.291	0.033	0.837	0.0278504	0.7998078	0.145	0.033	0.750
sp|O35684|	Serpini1*	NEUS_MOUSE Neuroserpin	−0.277	0.203	−0.298	0.166	−0.021	0.696	0.005	0.958	−0.012424	0.7553671	−0.007	0.936	1.000

Several members of the serpin family are specifically upregulated in P497S animals. The color shades correspond to the Log₂ ratios not significance.

^*Denotes the serpin proteins that were studied.