Table 1.
Demographic and clinical characteristics of the cohort study (n = 1525).
| Variables | N(%)/median (IQR) | Low-dose aspirin | p value | |
|---|---|---|---|---|
| Non-users | Users ≥ 180 days | |||
| Sex | ||||
| Female | 78(5.11%) | 58(4.75%) | 20(6.56%) | 0.2010 |
| Male | 1447(94.89%) | 1162(95.25%) | 285(93.44%) | |
| Age | ||||
| Year | 58(52–65) | 58(52–65) | 58(53–65) | 0.7997 |
| Pathological stages of cancer (AJCC)a | ||||
| I & II | 892(58.49%) | 711(58.28%) | 181(59.34%) | 0.7355 |
| III & IVb | 633(41.51%) | 509(41.72%) | 124(40.66%) | |
| Cancer recurrence | ||||
| No | 1222(80.13%) | 967(79.26%) | 255(83.61%) | 0.0890 |
| Yes | 303(19.87%) | 253(20.74%) | 50(16.39%) | |
| Mortality | ||||
| Alive | 1059(69.44%) | 816(66.89%) | 243(79.67%) | < 0.0001 |
| Death | 466(30.56%) | 404(33.11%) | 62(20.33%) | |
| Causes of death | ||||
| Alive | 1059(69.44%) | 816(66.89%) | 243(79.67%) | < 0.0001 |
| Death due to OSCC | 264(17.31%) | 235(19.26%) | 29(9.51%) | |
| Other-Causes of Death | 202(13.25%) | 169(13.85%) | 33(10.82%) | |
| Treatments | ||||
| Surgery | 857(56.2%) | 681(55.82%) | 176(57.7%) | 0.5528 |
| Surgery & RT or CCRT | 668(43.8%) | 539(44.18%) | 129(42.3%) | |
| Lifestyle risk factors | ||||
| Smoking | ||||
| No | 400(26.47%) | 322(26.68%) | 78(25.66%) | 0.7187 |
| Yes | 1111(73.53%) | 885(73.32%) | 226(74.34%) | |
| Betel nut chewing | ||||
| No | 637(42.16%) | 504(41.76%) | 133(43.75%) | 0.5293 |
| Yes | 874(57.84%) | 703(58.24%) | 171(56.25%) | |
| Alcohol consumption | ||||
| No | 665(44.01%) | 529(43.83%) | 136(44.74%) | 0.7753 |
| Yes | 846(55.99%) | 678(56.17%) | 168(55.26%) | |
| Comorbidities | ||||
| Atrial fibrillation (flutter) | ||||
| No | 1483(97.25%) | 1203(98.61%) | 280(91.8%) | < 0.0001 |
| Yes | 42(2.75%) | 17(1.39%) | 25(8.2%) | |
| DM | ||||
| No | 1171(76.79%) | 1023(83.85%) | 148(48.52%) | < 0.0001 |
| Yes | 354(23.21%) | 197(16.15%) | 157(51.48%) | |
| Hypertension | ||||
| No | 1082(70.95%) | 987(80.9%) | 95(31.15%) | < 0.0001 |
| Yes | 443(29.05%) | 233(19.1%) | 210(68.85%) | |
| Hyperlipidemia | ||||
| No | 1221(80.07%) | 1099(90.08%) | 122(40.0%) | < 0.0001 |
| Yes | 304(19.93%) | 121(9.92%) | 183(60.0%) | |
IQR Interquartile range, RT Radiotherapy, CCRT Concurrent chemoradiotherapy, DM Diabetes mellitus.
aPathological AJCC Cancer Staging 7th Edition.
bStages IVa and IVb only.