Table 6.

Receiver operating characteristics of salivary cytokines in non-stimulated saliva of stroke patients and healthy controls.

Salivary biomarker	NWS
	AUC	95% CI	p-value	Cut off	Sensitivity%	95% CI	Specificity%	95% CI
TNF-α
Concentration (pg/mL)	0.992	0.9760–1.000	< 0.0001	> 17.46	96	80.46–99.79	96	80.46–99.79
Output (pg/min)	0.8544	0.7470–0.9618	< 0.0001	> 4.727	76	56.57–88.50	80	60.87–91.14
Specific amount (ng/mg protein)	0.9712	0.9340–1.000	< 0.0001	> 15.61	92	75.03–98.58	92	75.03–98.58
IL-6
Concentration (pg/mL)	0.8976	0.7944–1.000	< 0.0001	> 22.08	84	65.35–93.60	96	80.46–99.79
Output (pg/min)	0.7376	0.5897–0.8855	0.004	> 5.602	76	56.57–88.50	72	52.42–85.72
specific amount (ng/mg protein)	0.9104	0.8168–1.000	< 0.0001	> 18.03	84	65.35–93.60	92	75.03–98.58
IL-10
Concentration (pg/mL)	0.9568	0.9078–1.000	< 0.0001	< 3.014	88	70.04–95.83	92	75.03–98.58
Output (pg/min)	0.776	0.6400–0.9120	0.0008	< 1.140	80	60.87–91.14	68	48.41–82.79
specific amount (ng/mg protein)	0.8848	0.7883–0.9813	< 0.0001	< 2.173	72	52.42–85.72	96	80.46–99.79
TNF-α/IL-10	0.9984	0.9931–1.000	< 0.0001	> 5.577	100	86.68–100.0	96	80.46–99.79
IL-6/IL-10	0.9792	0.9426––1.000	< 0.0001	> 7.625	92	75.03–98.58	100	86.68–100.0

TNF-α–tumor necrosis factor α; IL-6 – interleukin 6; IL-10 – interleukin 10.