Table 1.

The ncRNA networks that play a role in CNS

Network	Putative Function
Linc-RoR/miR-145	Human embryonic stem cell maintenance and differentiation by targeting transcription regulators Oct4, Sox2, and Nanog (Cesana et al., 2011; Wang et al., 2013)
Malat1 or TUG1/miR-145	Controls apoptosis by regulating aquaporin-4 following stroke (Shan et al., 2020; Wang et al., 2020a)
H19/138-5p	Regulates apoptosis & inflammation by targeting p65 after stroke (Li et al., 2020b; Wang et al., 2017)
Meg3/miR-424-5p	Regulate apoptosis by Sema3A/Cdc42/JNK pathway (Xiang et al., 2020)
CDR1as/miR-7	Regulate neuronal activity (Hansen et al., 2013; Piwecka et al., 2017)
circTLK1/miR-335-3p	Aggravates ischemic brain damage by derepressing TIPARP (Wu et al., 2019)
circTTC3/miR-372-3p	Promotes post-stroke brain damage in mice by targeting TLR4 (Yang et al., 2021)
circLrp1b/miR-27a	Promotes apoptosis following TBI by activating Bcl-2 family proteins Puma, Noxa, and Bax (Sabirzhanov et al., 2014; Xie et al., 2018)
circRNA-2960/miR‐124	Contributes to secondary damage after SCI (Chen et al., 2021)
circ_0000950/miR-103	Promote neuronal apoptosis and inflammation and suppresses neurite outgrowth in the AD brain (Yang et al., 2019)
circDLGAP4/miR-134-5p	Suppresses CREB and CREB target genes including BDNF, Bcl-2, and PGC-1α to modulates neuronal function in PD (Feng et al., 2020)
CDR1as/miR-7/Cyrano	Regulate miR-7 genes like α-synuclein, Fos, Nr4a3, Irs2 and Klf4 (Kim et al., 2018; Kleaveland et al., 2018; Piwecka et al., 2017)

2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase, TIPARP; Toll-like receptor 4, TLR4.