Fig. 7. Effects of inhibition of citrate synthase genes on metabolism of H. mediterranei.

Red and green arrows indicate upregulation and downregulation of gene expression, respectively. Numbers in brackets are log₂ (fold change). CS citrate synthase, ACO aconitase, ICD isocitrate dehydrogenase, OGDC α-ketoglutarate dehydrogenase, SUC succinyl-CoA synthetase, SDH succinate dehydrogenase, FUM fumarase, MDH malate dehydrogenase, PEP phosphoenolpyruvate, PEPC, PEP carboxylase, PYK pyruvate kinase, PPS phosphoenolpyruvate synthase.