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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: J Immunol. 2021 Aug 4;207(5):1419–1427. doi: 10.4049/jimmunol.2100266

Figure 5.

Figure 5.

SIRPα modulates multiple downstream signaling pathways during M1 macrophage polarization. A) The phosphorylation of P65, IKKα/β, ERK1/2, P38, JNK, STAT1, Akt1 and Akt2 in WT and Sirpα−/− BMDM in the absence or presence of mCD47.ex during M1 polarization. B) Signaling transduction in WT and Sirpα−/− BMDM in the absence or presence of mCD47.ex after LPS, CpG or Poly(I:C) treatment. C) The co-association of p85, SHP-1, and SIRPα during M1 activation. D) Model of SIRPα activation and its modulation on PI3K-Akt signaling through SHP-1 under M1 macrophage polarization.