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. 2021 Aug 25;12:5115. doi: 10.1038/s41467-021-25378-w

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Fig. 6 — Acute light stimulates ipRGCs, which directly activate majorly CRH and to a lesser extent TAC1 expressing GABAergic neurons in the POA. These GABAergic POA neurons form inhibitory monosynaptic connections with wakefulness-promoting regions, including the TMN, the LH, the VTA, and the DRN. POA, preoptic area; TMN, tuberomammillary nucleus; LH, lateral hypothalamus; VTA, ventral tegmental area; DRN, dorsal raphe nucleus.