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. 2021 Jul 7;108(8):1466–1477. doi: 10.1016/j.ajhg.2021.06.010

Figure 2.

Figure 2

Sperm morphology analyses for men harboring bi-allelic DNAH10 variants

(A) H&E staining for the spermatozoa obtained from a fertile control individual (NC) and men harboring bi-allelic DNAH10 variants. Compared to the spermatozoa of NC, which presented long, smooth tails (i), most spermatozoa obtained from men harboring DNAH10 variants displayed typical MMAF phenotypes, such as short (ii), absent (iii), coiled (iv), and irregular flagella (v). The data of H049 II-2 are shown as an example. Scale bars, 5 μm.

(B) SEM analysis of the spermatozoa obtained from a fertile control individual (NC) and men harboring bi-allelic DNAH10 variants. (i) Normal morphology of the spermatozoon from a healthy control male. (ii–vii) Most spermatozoa obtained from men harboring bi-allelic DNAH10 variants displayed typical MMAF phenotypes, including short (ii), absent (iii), bent (iv), coiled (v), and irregular flagella (vi and vii). The data of H049 II-2 are shown as an example. Scale bars, 5 μm.