Table 1.
Clinical and biochemical characteristics of the studied subjects.
| NC-AME | Controls | p value | |
|---|---|---|---|
| N | 28 | 27 | – |
| Male, n (%) | 11 (39.3%) | 12 (44.4%) | 0.6 |
| Age (years) | 51.1 [37.7–58.0] | 40.7 [33.2–49.8] | 0.14 |
| BMI (kg/m2) | 27.7 [26.1–30.1] | 26.5 [24.6–28.9] | 0.13 |
| SBP (mm Hg) | 141.0 [120.0–154.2] | 115.7 [108.7–119.0] | < 0.0001* |
| DBP (mm Hg) | 88.5 [78.7–97.5] | 74.7 [70.0–75.7] | < 0.0001* |
|
Serum cortisol (ug/dL) (nmol/L) |
9.9 [8.6–12.5] | 10.4 [7.4–16.7] | 0.8 |
| 273.1 [237.2–344.8] | 286.9 [204.1–460.7] | ||
|
Serum cortisone (ug/dL) (nmol/L) |
1.9 [1.8–2.1] | 2.4 [2.1–2.8] | < 0.0001* |
| 52.7 [49.9–58.3] | 66.6 [58.3–77.7] | ||
| Serum F/E ratio | 5.3 [4.7–6.1] | 4.4 [3.7–5.9] | 0.01* |
|
PRA (ng/ml*h) (ng/L/s) |
1.0 [0.7–1.8] | 1.5 [1.3–2.0] | 0.005* |
| 0.3 [0.2–0.5] | 0.4 [0.4–0.6] | ||
|
Aldosterone (ng/dl) (pmol/L) |
8.9 [5.4–13.6] | 7.5 [5.6–11.7] | 0.3 |
| 246.9 [149.8–377.4] | 208.1 [155.4–324.6] | ||
| Serum Na (mEq/L) | 141 [139–143] | 140 [139–141] | 0.2 |
| Serum K (mEq/L) | 4.1 [3.9–4.4] | 4.3 [4.0–4.4] | 0.4 |
| FeNa (24 h %) | 0.6 [0.4–0.8] | 0.7 [0.6–0.9] | 0.1 |
| FEK (24 h %) | 8.4 [6.3–10.7] | 6.7 [5.7–8.3] | 0.03* |
| Urinary Na (mEq/24 h) | 124 [86–173] | 141 [110–194] | 0.2 |
| Urinary K (mEq/24 h) | 49.5 [38.0–62.8] | 45.0 [27.0–59.0] | 0.2 |
| Urinary Na/K | 2.4 [1.6–3.5] | 3.5 [2.4–4.2] | 0.004* |
Values correspond to median [Q1–Q3].
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, F/E cortisol to cortisone ratio, PRA plasma renin activity, Na sodium; K+ potassium, FENa fractional excretion of sodium, FEK fractional excretion of potassium.
*p < 0.05, Mann–Whitney test.