Table 3.

Univariate and multivariable Cox regression models for 90-day ICU mortality

Univariate model	Variable	Univariable hazard ratio	95% CI	p value
	Demographic variablesrow
	CAPA	1.36	1.02–1.81	<0.001
	Age (per 5 years)	1.24	1.17–1.31	<0.001
	Female gender	1.07	0.82–1.39	0.607
	Study centre	0.96	0.95–0.98	<0.001
	Coexisting conditions
	Number of coexisting conditions	1.11	0.99–1.24	0.05
	Obesity	0.77	0.58–1.02	0.076
	Active malignant disease	1.68	1.12–2.51	0.013
	Solid organ transplantation	1.89	1.04–3.46	0.038
	Cardiovascular disease	1.33	1.04–1.72	0.021
	Pulmonary disease	1.35	0.98–1.77	0.060
	Diabetes mellitus	1.44	1.11–1.86	–0.001
	History of smoking	1.58	1.12-2.24	0.001
	Maximum Respiratory Treatment
	ECMO	0.99	0.65–1.51	0.982
	Invasive mechanical ventilation	1.05	0.81–1.35	0.708
	Non-Invasive ventilation	0.86	0.62–1.19	0.361
Multivariable Model	Variable	Multivariable hazard ratio	95% CI	p value
#1 (n = 592)	CAPA	1.77	1.31–2.37	<0.001
	Age	1.04	1.03–1.05	<0.001
#2 (n = 592)	CAPA	2.23	1.66–2.99	<0.001
	Study centre	0.96	0.94–0.98	<0.001
#3 (n = 592)	CAPA	1.97	1.46–2.67	<0.001
	Active malignancy	1.47	0.98–2.23	0.062
	Solid organ transplantation	1.38	0.74–2.58	0.304
	Cardiovascular disease	1.19	0.92–1.54	0.178
	Diabetes mellitus	1.31	1.00–1.72	0.047
	History of smoking	1.46	1.02–2.08	0.037
#4 (n = 592)	CAPA	1.68	1.23–2.28	0.001
	Age	1.04	1.03–1.06	<0.001
	Study centre	0.95	0.94–0.97	<0.001
	Active malignancy	1.30	0.86–1.97	0.207
	Solid organ transplantation	1.59	0.85–2.98	0.145
	Cardiovascular disease	0.84	0.64–1.09	0.204
	Diabetes mellitus	1.36	1.04–1.78	0.022
	History of smoking	1.50	1.04–2.15	0.028

Abbreviations: CAPA, COVID-19-associated pulmonary aspergillosis; COVID-19, coronavirus disease 2019; ECMO, extracorporeal membrane oxygenation.