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. 2021 Aug 12;11:710551. doi: 10.3389/fcimb.2021.710551

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Copyright © 2021 Fumagalli, Figueiredo and Aquino

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linear representation of (A) Ns2b protein with topology based on the ZIKV entry query uniprot Q32ZE1, (B) Ns4a protein with topology based on the DENV2 entry query uniprot Q9WDA6, (C) Ns4b protein with topology based on the DENV4 query uniprot Q2YHF0, and (D) Ns5 protein. Linear peptides are labeled by numbers and the antibody reactivity indicated by colors. The hydrophobicity prediction profile was determined using the amino acid sequence of the ZIKV (Genbank YP_002790881), DENV2 (Genbank ACA48840), DENV4 (Genbank CH99664), and TBEV (Genbank ADQ00969.1), with the Kyte & Doolittle hydropathy score scale (J. Mol. Biol. 157:105-132(1982). TM, Transmembrane region; IM, Intramembrane region.