Supplemental Table.
Demographic and clinical characteristics of the study population
| Demographics | Severity of SARS-CoV-2 infection |
|||
|---|---|---|---|---|
| Asymptomatic (n=696) | Mild (n=417) | Moderate (n=72) | Severe (n=38) | |
| Age (y) | 30.7 (26.4–34.9) | 31.6 (27.5–35.4)a | 32.6 (27.1–35.9)a | 32.8 (30.3–35.1)a |
| Weight (kg) | 69 (60–79) | 70 (61–81)a | 72 (62.5–83.8) | 80.5 (71.2–92.8)b |
| Height (cm) | 162 (157–166) | 163 (159–168)b | 162.5 (157–168) | 162 (160–165) |
| BMI (kg/m2) | 26.5 (23.4–30.4) | 26.3 (23.2–30.4) | 26.8 (24.5–30.9) | 30.1 (27.4–35.5)b |
| Race | ||||
| White | 342 (49.1) | 208 (49.9) | 22 (30.6)b | 14 (36.8) |
| Black | 99 (14.2) | 90 (21.6)b | 22 (30.6)b | 9 (23.7) |
| South Asian | 238 (34.2) | 97 (23.3)b | 25 (34.7) | 12 (31.6) |
| East Asian | 7 (1) | 6 (1.4) | 1 (1.4) | 0 (0) |
| Mixed | 10 (1.4) | 16 (3.8)a | 2 (2.8) | 3 (7.9)a |
| Diabetes | ||||
| None | 680 (97.7) | 412 (98.8) | 71 (98.6) | 36 (94.7) |
| Type I | 6 (0.9) | 2 (0.5) | 0 (0) | 0 (0) |
| Type II | 10 (1.4) | 3 (0.7) | 1 (1.4) | 2 (5.3) |
| History of preeclampsia | ||||
| Multiparous no PE | 413 (59.3) | 245 (58.8) | 41 (56.9) | 23 (60.5) |
| Multiparous PE | 11 (1.6) | 10 (2.4) | 2 (2.8) | 1 (2.6) |
| Nulliparous | 272 (39.1) | 162 (38.8) | 29 (40.3) | 14 (36.8) |
| Twins | 6 (0.9) | 6 (1.4) | 0 (0) | 1 (2.6) |
| Smoker | 51 (7.3) | 16 (3.8)a | 2 (2.8) | 1 (2.6) |
| Chronic hypertension | 13 (1.9) | 11 (2.6) | 1 (1.4) | 1 (2.6) |
| Conception method | ||||
| Spontaneous | 684 (98.3) | 406 (97.4) | 69 (95.8) | 38 (100) |
| In vitro fertilization | 12 (1.7) | 11 (2.6) | 3 (4.2) | 0 (0) |
| Birthweight (g) | 3210 (2825–3545) | 3268 (2900–3580) | 3090 (2520–3490) | 2320 (1657.5–2850)b |
| Preterm birth | 100 (14.4) | 66 (15.8) | 23 (31.9)b | 26 (68.4)b |
| Preeclampsia | 25 (3.6) | 14 (3.4) | 6 (8.3) | 6 (15.8)b |
| Fetal death | 7 (1) | 2 (0.48) | 1 (1.4) | 0 (0) |
| Miscarriage | 8 (1.2) | 7 (1.7) | 1 (1.4) | 0 (0) |
Continuous data are presented as median (interquartile range) whereas categorical data as number (percentage).
Differences between symptomatic groups and asymptomatic patients were assessed using t tests for continuous variables and Fisher exact test for categorical variables.
There were 11 hospitals in London (Kings College Hospital, Princess Royal Hospital, St Thomas’ Hospital, St Mary’s Hospital, Northwick Park Hospital, Homerton Hospital, The Royal London Hospital, Whipps Cross Hospital, Newham Hospital, Queen Elizabeth Hospital, Lewisham Hospital) and 3 in Birmingham (Birmingham Heartlands Hospital, Queen Elizabeth Hospital Birmingham and Good Hope Hospital).
BMI, body mass index; PE, preeclampsia.
Lai. SARS-CoV-2, preeclampsia, and preterm birth. Am J Obstet Gynecol 2021.
Significance P<.05 is denoted with respect to the asymptomatic group
Significance P<.01 is denoted with respect to the asymptomatic group.