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. 2021 Aug 12;12:715460. doi: 10.3389/fimmu.2021.715460

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Copyright © 2021 Lin, Gao, Wen, He and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic alterations between DDR-activated and DDR-suppressed subgroups. (A) Landscape of mutation profiles in HCC samples. Mutation information of each gene in each sample is shown in the waterfall plot. Top panel shows individual tumor mutation burden. The data shown were analyzed based on the TCGA data portal. (B) The mutation rate of TP53 was higher in the DDR-activated subgroup, while CTNNB1 was higher in the DDR-suppressed subgroup in the TCGA dataset. (C) The mutation rate of TP53 was higher in the DDR-activated subgroup, while CTNNB1 was higher in the DDR-suppressed subgroup in the ICGC dataset.