Table 3.

Univariate and Multivariate Cox Proportional Hazard Regression Analysis of Intravesical Recurrence-Free Survival

Variables	Univariate			Multivariate
	P-value	HR	95% CI	P-value	HR	95% CI
Age	0.49	1.01	0.97–1.06
Gender (male vs female) 0.952	0.94	0.96	0.36–2.54
Smoking history (yes vs no)	0.32	0.61	0.23–1.61
Tumor size (≥3 cm vs <3 cm)	0.14	1.90	0.80–4.49	0.10	3.88	0.74–20.2
Multiplicity (multiple vs single)	0.02*	2.37	1.10–5.08	0.02*	6.62	1.32–33.2
pT stage (pT1 vs pTa)	0.11	1.89	0.85–4.19	0.10	2.53	0.14–7.87
Grade (high vs low)	0.76	0.86	0.37–1.95
CIS (yes vs no)	0.06	0.42	0.17–1.03
EORTC scoring system	0.056	1.13	0.99–1.29	0.19	0.75	0.48–1.16
LAT1 expression (high vs low)	0.04*	2.29	1.01–5.22	0.01*	2.82	1.21–6.58

Note: *Statistically significant.

Abbreviations: CI, confidence interval; CIS, carcinoma in situ; EORTC, European Organization for Research and Treatment of Cancer; HR, hazard risk; IVR, intravesical recurrence.