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. 2021 Aug 26;23(Suppl C):C204–C220. doi: 10.1093/eurheartj/suab074

Table 2.

Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) classification for patients with advanced heart failure

INTERMACS stages for classifying patients with advanced heart failure
INTERMACS 1
  • Cardiogenic shock

  • ‘Crush and burn’

Haemodynamic instability in spite of increasing doses of catecholamines and/or mechanical circulatory support with critical hypoperfusion of target organs (severe cardiogenic shock).
INTERMACS 2 Progressive decline despite inotropic support ‘Sliding on inotropes’ Intravenous inotropic support with acceptable blood pressure but rapid deterioration of renal function, nutritional state, or signs of congestion.
INTERMACS 3
  • Stable but inotrope dependent

  • ‘Dependent stability’

Haemodynamic stability with low or intermediate doses of inotropics, but necessary due to hypotension, worsening of symptoms, or progressive renal failure.
INTERMACS 4
  • Resting symptoms

  • ‘Frequent flyer’

Temporary cessation of inotropic treatment is possible, but patient presents with frequent symptoms recurrences and typically with fluid overload
INTERMACS 5
  • Exertion intolerant

  • ‘Housebound’

Complete cessation of physical activity, stable at rest, but frequently with moderate fluid retention and some level of renal dysfunction
INTERMACS 6
  • Exertion limited

  • ‘Walking wounded’

Minor limitation on physical activity and absence of congestion while at rest. Easily fatigued by light activity
INTERMACS 7 ‘Placeholder’ Patient in NYHA Class III with no current or recent unstable fluid balance.