Table 3.
Genotypes of the six SYTL3-SLC22A3 SNPs and the risk of CAD and IS.
| SNP/model | Ref. genotype | Effect genotype | CAD (OR 95% CI) | PCAD | IS (OR 95% CI) | PIS |
|---|---|---|---|---|---|---|
| rs9364496 | ||||||
| Codominant | A/A | A/G | 1.26 (1.01–1.59) | 0.12 | 0.99 (0.79–1.25) | 0.99 |
| G/G | 1.01 (0.61–1.67) | 0.96 (0.59–1.58) | ||||
| Dominant | A/A | A/G+G/G | 1.23 (0.99–1.53) | 0.064 | 0.99 (0.79–1.23) | 0.93 |
| Recessive | A/A+A/G | G/G | 0.92 (0.56–1.52) | 0.76 | 0.96 (0.59–1.58) | 0.89 |
| Overdominant | A/A+G/G | A/G | 1.26 (1.01–1.58) | 0.041 | 1.00 (0.79–1.25) | 0.98 |
| Log-additive | 1.14 (0.95–1.37) | 0.15 | 0.99 (0.82–1.18) | 0.9 | ||
| rs6455600 | ||||||
| Codominant | C/C | C/T | 1.09 (0.87–1.36) | 0.74 | 1.01 (0.81–1.27) | 0.61 |
| T/T | 1.10 (0.73–1.64) | 1.22 (0.82–1.81) | ||||
| Dominant | C/C | C/T+T/T | 1.09 (0.88–1.35) | 0.44 | 1.05 (0.85–1.29) | 0.68 |
| Recessive | C/C+C/T | T/T | 1.06 (0.71–1.57) | 0.78 | 1.21 (0.83–1.77) | 0.32 |
| Overdominant | C/C+T/T | C/T | 1.07 (0.86–1.33) | 0.53 | 0.98 (0.79–1.22) | 0.89 |
| Log-additive | 1.06 (0.90–1.26) | 0.47 | 1.07 (0.90–1.26) | 0.45 | ||
| rs2129209 | ||||||
| Codominant | A/A | A/C | 0.82 (0.65–1.02) | 0.18 | 0.81 (0.65–1.02) | 0.063 |
| C/C | 0.82 (0.53–1.27) | 0.65 (0.41–1.03) | ||||
| Dominant | A/A | A/C+C/C | 0.82 (0.66–1.01) | 0.062 | 0.79 (0.64–0.98) | 0.031 |
| Recessive | A/A+A/C | C/C | 0.90 (0.59–1.37) | 0.62 | 0.71 (0.46–1.12) | 0.14 |
| Overdominant | A/A+C/C | A/C | 0.83 (0.67–1.04) | 0.1 | 0.85 (0.69–1.05) | 0.14 |
| Log-additive | 0.86 (0.73–1.02) | 0.086 | 0.81 (0.68–0.97) | 0.019 | ||
| rs9456350 | ||||||
| Codominant | A/A | A/G | 0.89 (0.69–1.16) | 0.67 | 0.99 (0.77–1.28) | 0.96 |
| G/G | 0.85 (0.34–2.12) | 1.13 (0.46–2.81) | ||||
| Dominant | A/A | A/G+G/G | 0.89 (0.69–1.15) | 0.37 | 1.00 (0.78–1.28) | 0.99 |
| Recessive | A/A+A/G | G/G | 0.87 (0.35–2.17) | 0.76 | 1.13 (0.46–2.81) | 0.79 |
| Overdominant | A/A+G/G | A/G | 0.90 (0.69–1.16) | 0.41 | 0.99 (0.77–1.28) | 0.95 |
| Log-additive | 0.90 (0.72–1.13) | 0.37 | 1.01 (0.80–1.27) | 0.94 | ||
| rs446809 | ||||||
| Codominant | C/C | C/A | 1.15 (0.92–1.45) | 0.064 | 1.20 (0.96–1.51) | 0.044 |
| A/A | 1.58 (1.06–2.36) | 1.65 (1.08–2.53) | ||||
| Dominant | C/C | C/A+A/A | 1.22 (0.98–1.52) | 0.08 | 1.25 (1.00–1.57) | 0.046 |
| Recessive | C/C+C/A | A/A | 1.47 (1.01–2.15) | 0.046 | 1.48 (0.99–2.22) | 0.054 |
| Overdominant | C/C+A/A | C/A | 1.07 (0.86–1.33) | 0.55 | 1.11 (0.89–1.37) | 0.37 |
| Log-additive | 1.22 (1.03–1.44) | 0.024 | 1.25 (1.05–1.49) | 0.014 | ||
| rs539298 | ||||||
| Codominant | A/A | A/G | 0.77 (0.62–0.96) | 0.0082 | 0.67 (0.53–0.84) | 0.0511 |
| G/G | 0.56 (0.36–0.88) | 0.66 (0.42–1.04) | ||||
| Dominant | A/A | A/G+G/G | 0.74 (0.60–0.91) | 0.0053 | 0.67 (0.54–0.83) | 2E-04 |
| Recessive | A/A+A/G | G/G | 0.63 (0.40–0.98) | 0.038 | 0.79 (0.51–1.22) | 0.28 |
| Overdominant | A/A+G/G | A/G | 0.82 (0.66–1.02) | 0.07 | 0.70 (0.56–0.87) | 0.0012 |
| Log-additive | 0.76 (0.64–0.91) | 0.002 | 0.74 (0.62–0.88) | 6E-04 | ||
SNP, single nucleotide polymorphism; CAD, coronary artery disease; IS, ischemic stroke. Adjusted for sex, age, smoking, drinking, BMI, diabetes, hypertension.