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. 2021 Aug 12;8:713068. doi: 10.3389/fcvm.2021.713068

Table 3.

Genotypes of the six SYTL3-SLC22A3 SNPs and the risk of CAD and IS.

SNP/model Ref. genotype Effect genotype CAD (OR 95% CI) PCAD IS (OR 95% CI) PIS
rs9364496
Codominant A/A A/G 1.26 (1.01–1.59) 0.12 0.99 (0.79–1.25) 0.99
G/G 1.01 (0.61–1.67) 0.96 (0.59–1.58)
Dominant A/A A/G+G/G 1.23 (0.99–1.53) 0.064 0.99 (0.79–1.23) 0.93
Recessive A/A+A/G G/G 0.92 (0.56–1.52) 0.76 0.96 (0.59–1.58) 0.89
Overdominant A/A+G/G A/G 1.26 (1.01–1.58) 0.041 1.00 (0.79–1.25) 0.98
Log-additive 1.14 (0.95–1.37) 0.15 0.99 (0.82–1.18) 0.9
rs6455600
Codominant C/C C/T 1.09 (0.87–1.36) 0.74 1.01 (0.81–1.27) 0.61
T/T 1.10 (0.73–1.64) 1.22 (0.82–1.81)
Dominant C/C C/T+T/T 1.09 (0.88–1.35) 0.44 1.05 (0.85–1.29) 0.68
Recessive C/C+C/T T/T 1.06 (0.71–1.57) 0.78 1.21 (0.83–1.77) 0.32
Overdominant C/C+T/T C/T 1.07 (0.86–1.33) 0.53 0.98 (0.79–1.22) 0.89
Log-additive 1.06 (0.90–1.26) 0.47 1.07 (0.90–1.26) 0.45
rs2129209
Codominant A/A A/C 0.82 (0.65–1.02) 0.18 0.81 (0.65–1.02) 0.063
C/C 0.82 (0.53–1.27) 0.65 (0.41–1.03)
Dominant A/A A/C+C/C 0.82 (0.66–1.01) 0.062 0.79 (0.64–0.98) 0.031
Recessive A/A+A/C C/C 0.90 (0.59–1.37) 0.62 0.71 (0.46–1.12) 0.14
Overdominant A/A+C/C A/C 0.83 (0.67–1.04) 0.1 0.85 (0.69–1.05) 0.14
Log-additive 0.86 (0.73–1.02) 0.086 0.81 (0.68–0.97) 0.019
rs9456350
Codominant A/A A/G 0.89 (0.69–1.16) 0.67 0.99 (0.77–1.28) 0.96
G/G 0.85 (0.34–2.12) 1.13 (0.46–2.81)
Dominant A/A A/G+G/G 0.89 (0.69–1.15) 0.37 1.00 (0.78–1.28) 0.99
Recessive A/A+A/G G/G 0.87 (0.35–2.17) 0.76 1.13 (0.46–2.81) 0.79
Overdominant A/A+G/G A/G 0.90 (0.69–1.16) 0.41 0.99 (0.77–1.28) 0.95
Log-additive 0.90 (0.72–1.13) 0.37 1.01 (0.80–1.27) 0.94
rs446809
Codominant C/C C/A 1.15 (0.92–1.45) 0.064 1.20 (0.96–1.51) 0.044
A/A 1.58 (1.06–2.36) 1.65 (1.08–2.53)
Dominant C/C C/A+A/A 1.22 (0.98–1.52) 0.08 1.25 (1.00–1.57) 0.046
Recessive C/C+C/A A/A 1.47 (1.01–2.15) 0.046 1.48 (0.99–2.22) 0.054
Overdominant C/C+A/A C/A 1.07 (0.86–1.33) 0.55 1.11 (0.89–1.37) 0.37
Log-additive 1.22 (1.03–1.44) 0.024 1.25 (1.05–1.49) 0.014
rs539298
Codominant A/A A/G 0.77 (0.62–0.96) 0.0082 0.67 (0.53–0.84) 0.0511
G/G 0.56 (0.36–0.88) 0.66 (0.42–1.04)
Dominant A/A A/G+G/G 0.74 (0.60–0.91) 0.0053 0.67 (0.54–0.83) 2E-04
Recessive A/A+A/G G/G 0.63 (0.40–0.98) 0.038 0.79 (0.51–1.22) 0.28
Overdominant A/A+G/G A/G 0.82 (0.66–1.02) 0.07 0.70 (0.56–0.87) 0.0012
Log-additive 0.76 (0.64–0.91) 0.002 0.74 (0.62–0.88) 6E-04

SNP, single nucleotide polymorphism; CAD, coronary artery disease; IS, ischemic stroke. Adjusted for sex, age, smoking, drinking, BMI, diabetes, hypertension.