Table 4.
Haplotype frequencies of the six SYTL3-SLC22A3 SNPs and the risk of CAD and IS.
| Haplotype | Control frequency | CAD | IS | ||||
|---|---|---|---|---|---|---|---|
| Frequency | OR (95% CI) | P | Frequency | OR (95% CI) | P | ||
| A-C-A-A-C-A | 0.4458 | 0.4446 | 1.00 | — | 0.4813 | 1.00 | — |
| A-C-A-A-A-G | 0.1052 | 0.1242 | 1.32 (0.94–1.84) | 0.11 | 0.0528 | 0.63 (0.42–0.95) | 0.027 |
| A-C-A-A-A-A | 0.0362 | 0.0645 | 2.19 (1.49–3.21) | 1E-04 | 0.0641 | 1.98 (1.39–2.84) | 2E-04 |
| G-T-C-A-C-A | 0.0398 | 0.0573 | 1.18 (0.78–1.79) | 0.43 | 0.0357 | 0.94 (0.58–1.54) | 0.820 |
| G-T-C-G-A-G | 0.0448 | 0.0403 | 0.97 (0.61–1.56) | 0.91 | 0.1175 | 2.79 (1.87–4.15) | <0.0001 |
| A-C-A-A-C-G | 0.0486 | 0.0236 | 0.52 (0.34–0.78) | 0.0016 | 0.0291 | 0.59 (0.40–0.88) | 0.0099 |
| G-T-C-G-C-A | 0.0264 | 0.0472 | 1.82 (1.07–3.10) | 0.026 | 0 | – | – |
| A-T-C-A-C-A | 0.0330 | 0.0366 | 1.13 (0.69–1.85) | 0.64 | 0.0341 | 0.75 (0.46–1.23) | 0.25 |
| A-T-A-A-C-A | 0.0195 | 0.0359 | 2.04 (1.14–3.66) | 0.016 | 0.0753 | 3.24 (1.92–5.48) | <0.0001 |
CAD, coronary artery disease; IS, ischemic stroke. The haplotypes consist of six alleles in the order of rs9364496, rs6455600, rs2129209, rs9456350, rs446809, and rs539298 SNPs. Adjusted for sex, age, smoking, drinking, BMI, diabetes, hypertension.